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[4] At the cellular level, free estradiol diffuses through cell membranes and binds to intracellular estrogen receptors and , which upon ligand activation dimerize and translocate to estrogen-response elements on nuclear DNA, modulating transcription of genes governing reproductive tract integrity, thermoregulation, bone metabolism, and vascular endothelial function

[2] The decline of GH results in reduced production of insulin-like growth factor (IGF-1), which typically works in tandem to manage and modulate our fat, protein, and glucose metabolism

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